Yu-Chien Wu, M.D. Ph.D.


Ph.D. University of Wisconsin - Madison, Madison, WI, USA
M.D. Kaohsiung Medical University, Kaohsiung, Taiwan

Research Interests

Dr. Wu joined the Department of Radiology and Imaging Science Faculty in 2013.  Her research focuses on diffusion magnetic resonance imaging (dMRI) to study white matter and gray matter structures of the human brain.  She pursues interests in both clinical applications and methodology development of dMRI techniques including Diffusion Tensor Imaging (DTI), q-space imaging (QSI), Diffusion Spectrum Imaging (DSI), High Angular Resolution Diffusion Imaging (HARDI), and Hybrid Diffusion Imaging (HYDI).  Her projects include: (1) developing an MRI pulse sequence for fast and high resolution dMRI, (2) exploring the time dependence of the water probability density function (PDF), (3) combining MultiVariate Pattern Analysis (MVPA) approaches and dMRI to segment white matter structures, (4) applying HYDI on clinical populations, and (5) implementing multimodal quantitative neuroimaging techniques for the early detection of brain pathologies. 



Selected publications

1  Hosseinbor AP, Chung MK, Wu Y-C, Alexander AL, Bendlin BB. A 4D hyperspherical interpretation of q-space. Med Image Comput Assist Interv 2014;16(3):501-509.

2  Hosseinbor AP, Chung MK, Wu Y-C, Alexander AL. Bessel Fourier Orientation Reconstruction (BFOR): An Analytical Diffusion Propagator Reconstruction for Hybrid Diffusion Imaging and Computation of q-Space Indices. NeuroImage 2012;64:650-670.

3  Samsonov A, Alexander AL, Mossahebi P, Wu Y-C, Duncan ID, Field AS. Quantitative MR imaging of two-pool magnetization transfer model parameters in myelin mutant shaking pup. Neuroimage 2012 Sep;62(3):1390-8.

4   Wu Y-C, Field AS, Duncan ID, Samsonov AA, Kondo Y, Tudorascu D, Alexander AL. High b-value and diffusion tensor imaging in a canine model of dysmyelination and brain maturation. NeuroImage 2011;58:829-837.

5   Wu Y-C, Field AS, Whalen PJ, Alexander AL. Age and Gender Related Changes in the Normal Human Brain using Hybrid Diffusion Imaging (HYDI). NeuroImage 2011;54:1840-1853.

6  Wu Y-C, Field AS, Alexander AL. Computation of Diffusion Function Measures in q-Space Using Magnetic Resonance Hybrid Diffusion Imaging. IEEE Trans Med Imaging 2008;27(6):858-865. 

7   Wu Y-C, Alexander AL. Hybrid Diffusion Imaging. NeuroImage 2007;36(3):617-629.

8   Wu Y-C, Alexander AL. A Method for Calibration Diffusion Gradients in Diffusion Tensor Imaging. J Comput Assist Tomogr 2007;31(6):984-993.

9   Field AS, Wu Y-C, Alexander AL. Principal Diffusion Direction in Peritumoral Fiber Tracts: Color Map Patterns and Directional Statistics. Ann NY Acad Sci 2005;1064:193-201.

10  Wu Y-C, Field AS, Badie B, Alexader AL. Quantitative Analysis of Diffusion Tensor Orientation: Theoretical Framework. Magn Reson Med 2004;52(5):1146-1155. 

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