News and Events
October 15, 2014 Drs. Yang Wang and Brenna McDonald find altered regional cerebral blood flow after pediatric concussion using ASL
Drs. Yang Wang and Brenna McDonald and colleagues have just had accepted for publication in Developmental Neuropsychology a study that details the use of arterial spin labeling in chronic pediatric mild traumatic brain injury (mTBI; i.e. concussion).
Your child may have or will experience concussion during their childhood—a little rest and parental care is usually what the doctor ordered. However, after concussion symptoms subside, the brain is still changing.
Concussion (mTBI) pathophysiology is at best poorly understood. It is a significant public health problem, since concussion can make a child more prone to developing emotional, behavioral, and cognitive problems. In addition, concussion makes the pediatric brain more susceptible to a second injury.
“Decreased cerebral blood flow in chronic pediatric mild TBI: an MRI perfusion study” is the first study of its kind to explore cerebral blood flow changes in mTBI. This is important for the development of novel therapeutics that could alleviate symptoms and prevent repeat injury.
“This is the first research paper to evaluate cerebral blood flow changes in pediatric mild traumatic brain injury using the advanced MR perfusion technique,” states Wang.
The investigative team measured cerebral blood flow (CBF) in order to understand the neurovascular mechanisms related to concussion and recovery, and how concussion impacts brain function and susceptibility to further injury.Wang and McDonald used arterial spin labeling (ASL) to noninvasively assess cerebral blood flow in chronic pediatric mTBI patients compared to healthy controls. ASL is an advanced MRI technique that uses magnetically labeled blood water for a tracer, dodging the traditional concerns of pediatric radiation exposure.
The study consisted of 14 adolescents with mTBI, who had a concussion due to participation in recreational sports 3-12 months previously. Healthy controls consisted of 15 adolescents with no history of concussion. Normal MRI and neuropsychological tests indicated no difference between the mTBI group and healthy controls.
Lower CBF in bilateral frontotemporal brain regions was found in the mTBI patients approximately seven months post-injury. These regions are important for executive function and decision making, and are regions undergoing active maturation in adolescence. Thus, Wang and McDonald concluded, pediatric concussion may trigger a pathophysiologic process that results in altered regional CBF.
McDonald noted, “These findings are important because they demonstrate persistent brain alterations well after the typical period of symptom recovery, which may help explain vulnerability to subsequent injury.” Exploring this process and the mechanism behind it may be useful in future development of novel therapeutics for concussion.
Complete list of authors:
Yang Wang, MD 1,2*, John D. West, MS 2, Jessica N. Bailey, BS 2, Daniel R. Westfall, BA 2,3, Hui Xiao, MD 2,4, Todd W. Arnold, MD 5, Patrick A. Kersey, MD 5, Andrew J. Saykin, PsyD 2, Brenna C. McDonald, PsyD 2*1 Center for Imaging Research, Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA; 2 Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; 3 Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA 4 Department of Radiology, Dongfang Hospital, Fujian, China; 5 St.Vincent Sports Performance, Carmel, IN, USA
October 6, 2014 Neuroscientists receive Nobel Prize for finding Spatial Navigation cells in the brain: http://www.nobelprize.org/nobel_prizes/medicine/laureates/2014/press.pdf
Friday, October 3, 2014 IUPUI Imaging Research Symposium IUPUI University Library, Lilly Auditorium10:00am – 3:00pm The objective of this Symposium was to bring together investigators from diverse scientific disciplines with image technology experts to explore potential collaborative research opportunities. This year’s event included a presentation by Dr. Kamlesh Lulla, Chief Scientist for Earth Observations from NASA’s Johnson Space Center who will describe recent activities in remote imaging. In addition, several IUPUI investigators presented their imaging-related research activities. These include applications in neuroimaging in Alzheimer’s disease, 3D imaging of the human airway, live cell imaging, and molecular probe development for tumor imaging among other topics. A poster session will provided opportunity for attendees to interact with several investigators who develop or utilize imaging technologies in their research. The target audience included researchers within the IUPUI/IU/PU community as well as academic and industrial investigators within the greater Indiana research community.
For more information, visit http://www.imaging.iupui.edu/events.php
September, 2014 Dr. Andrew J. Saykin was recently interviewed by Mike Jansen, Praxis Media Group, for a PBS series about storytelling. Dr. Saykin talked about how the brain processes information as it relates to learning.
August 28, 2014 Dr. Yang Wang will be missed as he joins the Medical School in the University of Wisconsin. Yang was with the I.U.S.M. for 15 years, making great contributions to the research here.
August 26, 2014 The Alzheimer's Association has chosen Shannon L. Risacher, Ph.D., as one of the 2014 New Investigator Research Grant recipient. NIRG Funds the next generation of promising scientists who have earned their doctoral degrees within the last 10 years. New Investigator Research Grants help to Promote Diversity (NIRGD) Funds new investigators from diverse backgrounds with intent to support early career development that will lay groundwork for future research grants.
August 19, 2014 Indiana University School of Medicine has purchased Siemens' most State-of-the-Art PRISMA 3T MRI scanner for patient care and research. It was installed in the Neuroscience Center by a crane large enough to hold this 30 ton machine. See more details here:
August 14, 2014 Ruth Lilly Medical Library Room 317. Candidate Talk: Chair, Medical and Molecular Genetics, Dr. Jason Moore, Third Century Professor; Professor, Genetics and Community and Family Medicine; Director, Institute for Quantitative Biomedical Sciences Geisel School of Medicine, Dartmouth College speaking on: “Network science approaches to the genetic analysis of common human diseases”.
Dr. Moore’s NIH-funded research program focuses on the development, evaluation and application of computational methods for identifying and characterizing gene-gene and gene-environment interactions in population-based studies of common human diseases. His work has been communicated in more than 380 publications and is supported by several NIH R01 grants including three from the National Library of Medicine. In 2011 he was elected a Fellow of the American Association for the Advancement of Science (AAAS) in recognition of his scholarship in the area of computational human genetics. He was selected as a Kavli Fellow of the National Academy of Sciences in 2013 and serves as founding Editor-in-Chief of the BioMed Central journal BioData Mining.
NSRI (Neuroscience Strategic Research Initiative) Grants Awarded recently:
Shannon L. Risacher, Ph.D. received a two-year grant for my project entitled “Visual biomarkers in preclinical and prodromal stages of Alzheimer’s disease.” The goal of this project is to evaluate measures of visual function and retinal morphology as biomarkers for AD in conjunction with known neuroimaging biomarkers of AD pathophysiology (i.e., advanced MRI and PET imaging) in a population of older adults at risk for cognitive decline.
Kwangsik Nho, Ph.D., was awarded a grant for a pilot project, where “we will perform whole genome sequencing on well-characterized participants from an extensively studied local cohort (Indiana Memory and Aging Study), which already has RNA-Seq and Proteomics data, and integrate cutting-edge ‘-omics’ data sets to better understand the molecular characteristics of Alzheimer’s disease (AD).”
Brenna McDonald, Ph.D. and Dr. Tom Talavage, Ph.D., of Purdue, are Co-PIs on a project titled “Multi-Site Evaluation of the Role of Deep Brain Structures in Long-Term Neurological Disorder after Traumatic Brain Injury”. The goal is to examine differences in MRI metrics of brain structure and function in children and adolescents who have experienced repetitive head impacts and/or concussion versus healthy controls who have not suffered traumatic brain injury, with an emphasis on white matter integrity and resting blood flow.
July 12 - 17, 2014 Drs. Andrew J. Saykin and Shannon L. Risacher presented at the Alzheimer's Association International Conference in Copenhagen, Denmark. You can find out what was presented here. The Center for Neuroimaging had a total of 13 presentations, with 2 of them being Oral.
July 2014 Published recently in the IN Scope weekly news for faculty, staff and students from the Indiana University School of Medicine: Exposure to TV violence related to irregular attention and brain structure . Congratulations to Drs. Tom Hummer and Yang Wang on their research findings.
June 2, 2014 IU School of Medicine Faculty members presented at American Society of Neuroradiology meeting in Montreal, May 17-22. Presentations were as follows:
Oral presentation: O-830 High Resolution Diffusion Tensor Imaging of the Optic Pathway in NF1 Patients with Readout-Segmented, Multi-Shot Echo Planar Imaging at 3 T C Ho1, J West1, C Lin1, S Kralik1, Y Wang1, D Porter2, A Saykin1, C Shih3
Oral Presentation: Odontogenic Infections—What Radiologists Should Know K Mosier
Oral presentation: O-456 Perfusion MR Imaging for Grading Pediatric Brain Tumors J Cardinal1, S Kralik2, A Kamer2, C Ho2
Oral presentation: O-197 Evaluation of a Novel Pulsed Arterial Spin Labeling Protocol in Pediatric Brain Tumors: A Feasibility Study in Comparison with Dynamic Susceptibility Contrast Perfusion C Ho1, S Kralik1, J Smith2, J Boaz2, L Ackerman2, D Fulkerson2, Y Wang1
Education Exhibit EE-78 Successful Use of the Amplatzer Vascular Plug II in the Setting of Acute Simultaneous Transection of the Cervical Internal Carotid and Vertebral Arteries D Murph1, D Hsu2, A DeNardo2
Electronic Education Exhibit eEdE-145 Rare and Aggressive Thyroid Carcinoma: You May Not Have Seen Them, But They May Have Seen You! J Sodergren1, S Kralik2, K Mosier2
Education Exhibit EE-65 Ectopic External Auditory Canal and Ossicular Formation in Goldenhar Syndrome N Supakul1, C Ho1
Electronic Education Exhibit eEdE-180 Fetal MR Imaging Technique: What Are We Looking for? N Supakul1, S Kralik1, C Ho1
Electronic Education Exhibit eEdE-55 The Faces of CNS Lymphoma M Broadbent1, P Mehta2, N Supakul2, I Wu2
Electronic Education Exhibit eEdE-187 Ultrafast MR Imaging Brain in Comparison with Head CT for the Diagnosis of Nonaccidental Trauma N Supakul1, S Kralik1, C Ho1O-862 Another Boring Case of NF2 – NOT!: Schwannomatosis N Koontz1, A Agarwal2, K Mosier2, L Shah3
Electronic Education Exhibit eEdE-02 Inferior Petrosal Sinus Sampling: What, Where, When, Why and How N Supakul1, J Tejada1This exhibit was awarded with an invitation for publication in the peer reviewed journal Neurographics.
May 30, 2014 Andrew J. Saykin, Psy.D., is invited to lecture at Washington University NIAC Seminar Series Lecture on 5/30/14. The title of his talk is “A Million Voxels and Three Billion Base Pairs: Challenges and Opportunities in the Imaging Genomics of Alzheimer’s Disease”
May 29, 2014 IU Simon Cancer Center hosts Cancer Research Day, with speakers Brenna McDonald, Psy.D.,MBA and Keynote Speaker Tim Ahles, Ph.D., who has collaborated with several faculty members in the Center for Neuroimaging. Read all about it here: http://cancer.iu.edu/education/crd/index.shtml
May 28th, 2014 Brenna McDonald, Psy.D.,MBA was recently in the News:
INVITED PODCAST: McDonald, B. C. (2014). Breast cancer chemotherapy effects on brain activation during multitasking and relation to cognitive complaints. Journal of Clinical Oncology. FEATURE STORY: http://www.reuters.com/article/2014/05/27/us-chemo-brain-mri-idUSKBN0E72IV20140527.
May 21-24 2014 Dr. Dan Albrecht and his supervisor Dr. Karmen Yoder are presenting The 10th International Symposium on Functional Neuroreceptor Mapping of the Living Brain (Amsterdam, The Netherlands. NRM is a biennial international meeting attended by a range of experts in the neuroPET field. Topics range from novel tracer development, advances in tracer kinetic modeling, and application of PET neuroligands in both small animal models and human populations.
The posters they are presenting are: Albrecht DA, Christian BT, MacKie P, Yoder KK. (2014) Differences in dopamine function in fibromyalgia.
Yoder KK, Albrecht DS, Dzemidzic M, Herring CM, Walters JW, Hile KL, O’Connor SJ, Kareken DA. (2014) Intravenous alcohol-induced dopamine release occurs in different striatal subregions in nontreatment-seeking alcoholics and social drinkers.
Oberlin BG, Albrecht DS, Walters JW, Hile KL, Kareken DA, Yoder KK. (2014) Correlation of ventral striatal dopamine receptor availability and impulsive choice in alcoholics and social drinkers.
Yoder KK, Territo PR, Hutchins GD, Hannestad JO, Morris ED, Gallezot J-D, Normandin MD, Cosgrove KP. (2014) Comparison of Standardized Uptake Values with Volume of Distribution for Quantitation of [C11]PBR28 Brain Uptake.
Yoder KK, Liu N, Riley AA, McCarthy BP, Persohn S, West JD, Dzemidzic M, Territo P, Xu X (2014) Changes in brain blood flow and metabolism in a mouse model of traumatic brain injury are detectable with [64Cu]PTSM and [18F]FDG PET.
May 12 - 16, 2014 Six faculty from Imaging Sciences (Saykin, Lin, Wu, Wang, Dydak, Tirkes) as well as 2 graduate students (Ma, Yeh) presented their research findings last week at the Joint Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM) and the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) in Milan, Italy. Dr Saykin gave an invited talk on GWAS Studies of Imaging Phenotypes. The following two oral presentations and 11 posters were presented:
The 22th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Milan, Italy
1. Andy Saykin, GWAS Studies of Imaging Phenotypes (invited talk for Educational Course on MRomics)
2. Wu Y-C, Kodiweera C. Rotating Short-Axis EPI "blades" as veering diffusion gradient directions with composite reconstruction (RSA)
3. Ma R, Stock AK, Zauber SE, Murdoch JB, Dharmadhikari S, Long Z, Beste C, Dydak U. Manganese Induced Changes In Thalamic GABA Levels Influence Cognitive and Motor Performance.
1. Lin C, Liu K, Spottiswoode B, Buckwalter K. Feasibility of Hip Prosthesis Imaging at 3T.
2. Le Y, Kroeker R, Geppert C, Dale B, Kipfer HD, Lin C. A Simulation Study of the TWIST View Sharing Impact on the Breast DCE MRI.
3. Tirkes T, Lin C, Wang C, Mouser H, Kakarala B, Akisik F. Correlation of T1-weighted Gradient Echo (GRE) Signal Intensity and Decreased Exocrine Function in Suspected Early Chronic Pancreatitis.
4. Pooley RA, Gorny KR, Favazza CP, Felmlee JP, Lin C, Bernstein MA, Wharen RE. Temperature Measurements of Deep Brain Stimulator Lead Tip in Phantom With MR Body Coil RF Transmit.
5. Stirling BD, Wu Y-C, Sha L, Haxby J, Whalen PJ. Automated Segmentation of the Human Amygdala using High Angular Diffusion Imaging (HARDI) and Spectral k-means Clustering.
6. Kodiweera C, Alexander AL, Wu Y-C. Age and Gender - Related Changes in the Normal Human Brain Using Hybrid Diffusion Imaging (HYDI) with Neurite Orientation Dispersion and Density Imaging (NODDI) Analysis.
7. Dydak U, Ward EJ, Ma R, Snyder S, Zauber SE, Murdoch JB, Long Z, Rosenthal F. Occupational Manganese Exposure Levels Correlate with Brain GABA Levels.
8. Yeh CL, Zauber SE, Snyder S, Long Z, Dydak U. Motor and Cognitive Processing Networks show increased Manganese Accumulation in Metal Workers.
9. Dharmadhikari S, Yildiz A, Quetscher C, Chmielewski W, Dydak U, Beste C. Higher Striatal GABA Relates To A More Serial And Efficient Mode Of Action Cascading And Stronger Attentional Gating In Airplane Pilots.
10. Dharmadhikari S, Casjens S, Glaubitz B, Lehnert M, Quetscher C, Lotz A, Brüning T, Schmidt-Wilcke T, Beste C, Pesch B, Woitalla D, Dydak U. Correlation of GABA Levels and Motor Performance in Parkinson’s disease.
11. Long Z, Jiang YM, Li XR, Xu J, Yeh CL, Long LL, Zheng W, Murdoch JB, Dydak U. Increased Thalamic GABA and Decreased Glutamate-Glutamine in Chronic Manganese-exposed Metal Workers and Manganism Patients.
Dr. Andrew J. Saykin was invited to Lecture, GWAS Studies of Imaging Phenotypes, “MRomics” CCET Weekday Course, Organizers: James Gee, PhD, Kristine Glunde, PhD, & Elizabeth Morris, MD, 2014 Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Milan, Italy, May 14, 2014.
March 28, 2014
Drs. Brenna McDonald and Andrew Saykin, who spoke at the Indiana Health Law Review Symposium at the Indiana University Robert H. McKinney School of Law. The title of the symposium was Neuroscience and Law: Injury, Capacity, and Illness. Dr. McDonald served on the Child Contact Sports and Concussion panel (10:00-10:45 AM), while Dr. Saykin served on the Predictive Testing, Decision-Making, and Ethics panel (1:45-3:00 PM). For a complete symposium program, visit http://mckinneylaw.iu.edu/health-law/_brochures/IHLR-Symposium-2014.pdf
March 21, 2014
The Neuroscience Center will host the Indiana Alzheimer Disease Center (IADC) Scientific Symposium on Alzheimer's Disease: Early Detection and Intervention in the Goodman Hall Auditorium. Registration begins at 7:45 to hear speakers:
Andrew Saykin, PsyD, Raymond C. Beeler Professor of Radiology & Imaging Sciences and Director of the IADC, IUSM. Early Detection: The Role of Neuroimaging and Biomarkers
Eric Siemers, MD, Senior Medical Director of the Alzheimer’s Disease Team, Eli Lilly & Co. Development of Promising Early Treatments and Interventions
Benjamin G. Druss, M.D., M.P.H., Rosalynn Carter Chair in Mental Health, Department of Health Policy and Management, Rollins School of Public Health at Emory University. Improving Health and Healthcare for People with Serious Mental Illnesses: From Research to Practice and Back Again
Kelly Griese, Investor Education Coordinator, Indiana Secretary of State; and Brandy R. Matthews, MD, Assistant Professor of Clinical Neurology, Neurology Residency Program Director, Department of Neurology; Associate Leader, IADC Education Core, IUSM Preventing Elder Investment Fraud: Assessing for Vulnerability
Christopher M. Callahan, MD, FACP, Cornelius & Yvonne Pettinga Professor of Medicine, Department of Internal and Geriatric Medicine; Director, IU Center for Aging Research; Scientist, Regenstrief Institute, IUSM. Testing Interventions in the Home: The ADMIT Trial
Jill R. Murrell, PhD, Associate Professor, Department of Pathology & Laboratory Medicine and Medical and Molecular Genetics, IUSM. Genetics and Early Diagnosis
Frederick Unverzagt, PhD, Professor of Psychiatry, Director, Clinical Neuropsychology Residency, Department of Psychiatry; Associate Leader, IADC Clinical Core, IUSM. Update on Mental Engagement and Physical Exercise: Recipe for Successful Aging?
Drs. Yang Wang and Brenna McDonald will be presenting back-to-back abstracts at the Tenth World Congress on Brain Injury in San Francisco. The session “Neuroimaging of Pediatric TBI” is Friday the 21st. Visit http://ibia.conference-services.net/programme.asp?conferenceID=3754 for more information on the conference. Wang's talk is on "Decreased cerebral blood flow in chronic pediatric mild traumatic brain injury: an MRI perfusion study". McDonald will present "Increased Frontal Activation during Working Memory Processing after Pediatric Concussion: Persistent Effects up to One Year Post-Injury"
January 23, 2014
I.U. School of Medicine Researchers awarded $300,000 in new grants from GE/NFL. Read more about it here: http://news.medicine.iu.edu/releases/2014/01/nfl-ge-concussion-study.shtml For General Electric's press release click here: http://www.genewscenter.com/Content/Detail.aspx?ReleaseID=17630&NewsAreaID=2&ClientID=1 .
October 25th, 2013
The Third Indiana Neuroimaging Symposium held on the Indiana University campus. It was held in Alumni Hall with Registration begining at 8:00 am and Opening Remarks by Sharlene Newman and Dean Larry Singell. Andrew J. Saykin, Psy.D. spoke on "A Million Voxels and Three Billion Base Pairs: Challenges and Opportunities in the Imaging Genomics of Alzheimer's Disease". Also from the IU School of Medicine, David Kareken, Ph.D. talked about Multi-modal neuroimaging of alcoholism risk. Following a Poster Session there were breakout sessions. Other speakers included IU Bloomington Faculty members, Olaf Sporns Ph.D. as the Keynote, and Thomas Schoenemann Ph.D. From Purdue, were speakers Ulrike Dydak Ph.D. and Thomas Talavage, Ph.D.
October 18, 2013
The annual meeting of the Indianapolis Chapter of the Society for Neuroscience was in Hine Hall on IUPUI campus.
Altered salience network connectivity in older adults with cognitive complaints, early and late amnestic mild cognitive impairment. JD Contreras, Y Wang, SL Risacher, BC McDonald, JD West, and AJ Saykin.
Cerebral hypometabolism in carriers of the intron 10 +3 MAPT mutation. KD Deters, SL Risacher, MR Farlow, FW Unverzagt, DA Kareken, GD Hutchins, KK Yoder, JR Murrell, S Spina, F Epperson, AJ Saykin, and B Ghetti.
In vivo measurement of neurotoxic changes in manganese-exposed workers. Z Long, Y-M Jiang, X-R Li, J Xu, L Long, W Zheng, JB Murdoch, and U Dydak.
Plasma cortisol is associated with accelerated brain atrophy: An Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. P Rajagopalan, B Gutman, AW Toga, CR Jack Jr., MW Weiner, and PM Thompson.
Increased frontal activation during working memory processing after pediatric concussion: Persistent effects up to one year post-injury. DR Westfall, JN Bailey, LK Stickans, KA Campbell, JD West, TW Arnold, PA Kersey, AJ Saykin, and BC McDonald.
October 9, 2013
The IUPUI Imaging Research Symposium was held in the University Library, Lilly Auditorium. Speakers included Gary D. Hutchins, PhD and two invited speakers. Daniel C. Sullivan, MD from Duke University Medical Center and Andrew J. Bowling, PhD of Dow AgroSciences in Indianapolis.
September 20, 2013
Andrew Saykin, Psy.D., spoke at the Seventh Annual Martin Family Alzheimer’s Caregiver Symposium, “Mind Your Health and Exercise Your Brain.” Dr. Saykin, Director of the Indiana Alzheimer Disease Center and Raymond C. Beeler Professor of Radiology and Imaging Sciences, presented “Imaging, Biomarkers and Subjective Cognitive Decline: How Early Can We Detect Alzheimer’s Disease?”
This free, all day event was designed for family caregivers and community health care providers, the Indiana Alzheimer Disease Center hosted the symposium at the IU Health Neuroscience Center (Goodman Hall) Auditorium. Tours were given of the imaging facilities and many written materials were offered.