Search

Facilities

IU Health Neuroscience Center Facilities

The IU Health Neuroscience Center is a premier center that combines IU Health’s comprehensive neurological services into a single location for a more integrated approach to clinical care and research. The facility is located just south of IU Health Methodist Hospital and a few blocks north of the IUPUI campus. Phase I of the Neuroscience Center, an ambulatory care and imaging facility, opened in August 2012. The ambulatory care center includes outpatient clinics and office space for clinicians and researchers affiliated with Psychiatry, Physical Medicine & Rehabilitation, Radiology and Imaging Sciences, Neurology, Neurological Surgery, and Neuropsychology. This new state of the art facility also houses cutting edge imaging instruments for both clinical and research use. The dedicated research imaging facilities include a Siemens Magnetom Skyra 3T MRI, a Siemens Magnetom Prisma 3T MRI, as well as a Siemens Biograph mCT.

 

Siemens MAGNETOM Skyra 3T MRI. A research-dedicated Siemens MAGNETOM Skya 3T 70cm bore whole body scanner was installed in June 2012. Key features include: XQ-gradient providing gradient strength up to 45 mT/m (72 mT/m effective), slew rate up to 200 T/m/s (346 T/m/s effective), up to 50 cm FOV and AudioComfort noise reduction; RF system with 64 receive channels supporting up to 204 coil elements; multiple RF coils including a 32-channel dedicated head coil, a 20-channel Head and Neck Coil as well as an array of other anatomy coils (neck, cardiac, etc.); Syngo D11 software with InLine Automated Processing, Auto Align slice positioning, Phoenix image reproducibility, Intelligent Coil Control auto coil position detection, full suite of imaging techniques (inline 3D and SSH EPI fMRI, up to 512 direction DTI/DSI, 3D ASL, SWI, etc.), syngo advanced imaging applications, iPAT2 utilizing mSENSE and GRAPPA technologies to increase image quality and reduce susceptibility artifacts. IDEA and ICE development environment and analysis packages are also available. 

Siemens MAGNETOM Prisma 3T MRI. A research-dedicated Siemens MAGNETOM Prisma 3T 60cm bore whole body scanner was installed in August 2014. Key features include: Zero helium boil-off technology, gradient strength up to 80 mT/m at  slew rate up to 200 T/m/s, up to 50 cm FOV; RF system with 64 receive; Magnet homogeneity at 40 cm DSV – 0.25 ppm; multiple RF coils including the newly FDA approved  64-channel  Head and Neck coil, a 20-channel Head and Neck Coil as well as an array of other anatomy coils (neck, cardiac, shoulder, knee, etc.); Tim 4G +Dot, Tim TX True Shape, Syngo D13 software with InLine Automated Processing, Auto Align slice positioning, Phoenix image reproducibility, Intelligent Coil Control auto coil position detection, full suite of imaging techniques, including multi-nuclear, advanced cardiac,  Syngo advanced neuroimaging applications. IDEA and ICE development environment and analysis packages are also available.

 

Siemens Biograph mCT. A research-dedicated Siemens Biograph mCT PET/CT scanner was installed in June 2012. PET features include: TrueV technology for extended FOV up to 78 cm; HD?PET and ultraHD?PET/Siemens Time of Flight technology for 2mm intrinsic resolution and improved sensitivity; TrueC, model-based Compton scatter correction; patented high-density 4x4x20mm LSO detectors with decay time of 40ns and coincidence timing of 4.5ns; HI-REZ detectors; sinogram mode and dynamic listmode data acquisition capabilities; multiple filter selections and algorithms for reconstruction, including OSEM and FBP. CT features include 128-slice CT with STRATON X-ray tube with 0.3s CT rotation speed, Adaptive Dose shielding and CARE Dose4D, z-Sharp technology for 0.33mm isotropic resolution, and Adaptive 4D Spiral technology for full-coverage perfusion studies. 

Tracer and Contrast Agent Development Facility

The Biomedical Research and Training Center (BRTC), houses our tracer and contrast agent development program. This facility consists of a cyclotron laboratory for the production of short-lived radionuclides, a radiation chemistry laboratory for the synthesis of drugs labeled with the radionuclides produced by the cyclotron, an analytical chemistry laboratory for measuring the sterility and pyrogenicity of the labeled drugs, and an automated pneumatic transport system for transporting PET radiopharmaceuticals to the imaging suite for measuring the 3D distribution of these drugs in the animal and human body following administration.

Cyclotron Laboratory. Housed within the cyclotron facility is a Siemens Radionuclide Delivery System (RDS), Eclipse RDS-111 cyclotron. This system consists of an 11 MeV proton cyclotron, irradiation target systems for the production of [11C], [13N], [15O], and [18F] radioactive material transport systems, and a series of computer-controlled synthesis modules for the production of radiopharmaceuticals.

Radiation Chemistry Laboratory. The 4 radiation chemistry laboratories at the BRTC consist of a series of shielded chemistry cells for the production of radiopharmaceuticals labeled with positron emitting radionuclides produced by the cyclotron. These cells are designed to hold several curies of radioactive material with minimal exposure to the personnel performing the syntheses. This laboratory also houses chromatography equipment for the isolation of radiopharmaceuticals from radiochemical contaminants produced in the synthetic process as well as analytical equipment for the measurement of radionuclide quantities.

 

Analytical Chemistry Laboratory. The analytical chemistry laboratory is used to assay small samples of the radiopharmaceuticals produced in the radiation chemistry laboratory. This laboratory contains assorted chromatography and sample assay equipment for these purposes. This laboratory is also used to assay human blood radiopharmaceutical concentrations and metabolites. Equipment used for the blood sample analysis includes an automated well counter system, centrifuge, and assorted separation columns for isolating radiopharmaceuticals from metabolites formed in the human body. The facility at BRTC houses 3 analytical chemistry laboratories.

Cold Chemistry Laboratory. The 6 cold chemistry laboratories in the BRTC are used for the synthesis of non-radioactive precursor compounds required for the synthesis of research radiopharmaceuticals.

Automated Pneumatic Transport System for PET Radiopharmaceuticals. A pneumatic transport system was established between our cyclotron/radiochemistry facilities and the PET imaging suites that are separated by a distance of ~2 km. Unique features of this system include a path which crosses a river, a 3-way networked computer control system, and novel carrier designs.

PET Tracer Production. PET [11C] and [18F] tracers, novel and potent enzyme-based and/or receptor-based brain, tumor and heart imaging agents are produced for PET to study brain, cancer and cardiovascular diseases. Numerous tracers are in various stages of development for support of research. The following list, although not exhaustive, illustrates the breadth of neuroscience, cancer, and cardiovascular-related radiopharmaceuticals at various stages of development, from initial evaluation in cell and animal models to evaluation in clinical trials.

Routine Tracers:

 

  1. [18F]FDG                                                                                                         Glucose metabolism
  2. [18F]Fluoride                                                                                        Bone Scanning                       
  3. [18F]Fluoromethane                                                                 Perfusion
  4. [11C]CO                                                                                                           Blood Volume                                                                               
  5. [11C]Acetate                                                                                        Free Fatty Oxidation Rates
  6. [15O]H2O                                                                                                          Blood Flow
  7. [15O]O2                                                                                                                                                                                                        Oxygen Consumption
  8. [13N]NH3                                                                                                          Blood Flow

 

Neuroimaging Tracers:

 

  1. [11C]CFT and [11C]CIT                                                                  Dopamine and Serotonin transporters    
  2. [11C]Raclopride                                                                             D2 receptors
  3. [11C]PIB                                                                                                     b-Amyloid plaques
  4. [11C]DAA1106                                                                                           Peripheral benzodiazepine receptor
  5. [11C]PBR28                                                                                               Peripheral benzodiazepine receptor
  6. [11C]Flumazenil                                                                             Benzodiazepine receptor
  7. [11C]Choline                                                                                              Brain Tumors
  8. [11C]Yohimbine                                                                              a2 Adrenergic receptors
  9. [11C]DTBZ                                                                                                 Vesicular monoamine transporters

10.  a-[11C]Methyl-L-tryptophan (a-[11C]AMT) Serotonin synthesis

11.  NK-1 Radioligands                                                                        NK-1 receptors

12.  D2/D3 Radioligands                                                                       D2/D3 receptors

13.  Glioma Radioligands                                                                     Glioma

14.  SKCa channel blockers [11C]NML                          SKCa channels

15.  Arylbenzothiazoles                                                                        b-Amyloid plaques

16.  Stilbene derivatives                                                                       b-Amyloid plaques

17.  Tetrahydroisoquinoline derivatives                       AMPA receptors

 

Other Relevant Tracers (Cancer & Cardiovascular Programs):

  1. Radiolabeled MMP inhibitors                                                        Matrix metalloproteinase (MMP) enzymes
  2. Radiolabeled O6-benzylguanine analogues          DNA repair protein MGMT enzyme
  3. Radiolabeled luciferin derivatives                         Luciferase gene
  4. [11C]Choline                                                                                                          Choline kinase
  5.  [18F]SU11248                                                                                                       Tyrosine kinase
  6. Stilbene derivatives                                                                                   Aryl hydrocarbon receptor
  7. Sulfonanilide analogues                                                                Aromatase
  8. Arylbenzothiazoles                                                                                    Tyrosine kinase
  9. Triphenylacetamides                                                                                 Nuclear factor k-B (NFk-B)
    10.  [18F]FES                                                                                                                Estrogen receptors

11.  Radiolabeled cyclofenil derivatives                                   Estrogen receptors

12.  Tetrahydroisoquinoline derivatives                                   Glioma

13.  Tetrahydroisoquinoline derivatives                                   Selective estrogen receptor modulators (SERMs)

14.   [11C]Neostigmine, Pyridostigmine                                    Acetylcholinesterase (AChE)

15.  [11C]HC-15, [18F]HC-15, [11C]HC-3, [18F]HC-3  High-affinity choline uptake (HACU)

16.  Rivastigmine derivatives                                                               Acetylcholinesterase (AChE)     

Image Processing and Data Analysis Computing

Super Computing and Massive Data Storage Systems:

We have access to the following supercomputers and storage systems:

The following computer systems and programs are available in the IU Health Neuroscience Center to aid us in the collection and analysis of data under the proposed project:

MR Imaging and Stimulus Delivery Equipment

Indiana University Center for Neuroimaging (CfN) | Department of Radiology | 355 West 16th Street, GH 4100 | Indianapolis, IN 46202 | PHONE: (317) 963-7229 | FAX: (317) 963-7547